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The Necromorphs' motivations are to create a mass of necrotic flesh that can be collected by the Markers during Convergence with the intention of creating another Brethren Moon, perpetuating the Moons' galaxy-wide cycle of extinction. The Necromorphs are controlled via the Markers by a group of entities known as the Brethren Moons, which are massive, highly intelligent beings created after a Convergence Event is initiated by a Marker. They are believed to be the heralds of humanity's ascension by certain Unitologists and individuals suffering from Marker Dementia, but on a more practical level, they are the extremely dangerous result of the exposure of dead tissue to the Markers' signal.

The sole purpose of all Necromorphs is to acquire more bodies to convert and spread the infection. The resulting creatures are extremely aggressive and will attack any uninfected organism on sight. Necromorphs are mutated corpses reshaped into horrific new forms by a recombinant extraterrestrial infection derived from a genetic code etched into and transmitted by the Markers.

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